The Farber lab uses Systems Genetics in the mouse to identify novel genes and gene networks involved in bone development with an emphasis on factors affecting the function of bone-forming osteoblasts.
Systems Genetics: Our Approach
Systems Genetics of Complex Skeletal Phenotypes
Systems genetics seeks to understand how genetic information is integrated, organized and transmitted through cellular networks to impact cellular function/behavior. Much of our work in the lab uses systems genetics approaches that integrate genetic and transcriptome data to identify individual genes and gene networks influencing complex skeletal phenotypes.
Example Papers: Mesner et al. Bicc1, Farber et al. Asxl2, Calabrese et al. Plos Genetics.